I think no, it takes one file at one time. Here is the syntax:
[mahmood@localhost ~]$ lxsplit
LXSplit v0.2.4 by Richard Stellingwerff, O. Sezer.
Home page: http://lxsplit.sourceforge.net/
Usage: lxsplit [OPTION] [FILE] [SPLITSIZE]
-j : join the files beginning with the given name
-s : split the given file. requires a valid size
Splitsize examples: 15M, 100m, 5000k, 30000000b
lxsplit -s hugefile.bin 15M
lxsplit -j hugefile.bin.001
there is one other software, mp3splt, which can split multiple files, but it splits based on timings not size. hence it takes a lot of time.