I should clarify. My wife has my 'ahem' in a bind - some time ago, I bought four 701 EeePCs: one for her, and one for each of her sisters. None of them are in any sense computer adept, they can barely use Windows. I have no intention of sticking Windows on those machines though, as three of them are going to end up in the Philippines - aka virus heaven; they'd be crapped within days, and it's not so easy to shoehorn XP Pro into a 4GB EeePC when it does crap out and some local may attempt to "fix" it. MiniMe 2009.1 is what I'm intending instead, and I'm looking for a way to make it as completely idiot-proof as possible. As my wife has demonstrated that all they'll ever be using is a few basic apps, I think the goal may be attainable - and I also think that PCLinuxOS is ideal for the task. I've been looking at others, particularly Puppy and Slax, but I still don't see them as being as usable; overall, KDE 3.5 is in my opinion still the best desktop for someone who's only ever used Windows.
So; a minimalistic install, with /home by itself on an SDHC card (for easy replacement/expansion, and also to keep it out of the way), and a bootable USB stick to automagically re-inject the system back into the Eee when, as you say, "disaster strikes" (ie; some local does attempt to install XP on it, and bricks the machine up?).
Or at least that's my current hallucination - I may harbour yet a few more strange notions, as time moves on. ;-)