As a malariologist who lives and works in Zambia, I think calling Gates a crook is way below the belt. I am no fan of M$ or their business practices, but the video you posted simply shows complete ignorance of the real situation. Gates have partnered with Glaxo to accelerate vaccine development. To safeguard prices, they have ensured that Glaxo will only sell the vaccine at cost price +5% (bearing in mind the hundreds of millions of dollars that Glaxo have invested, it will be some time before they recover this investment). Ultimately all companies need to make money / break even. There is no info yet on the pricing for this vaccine - for all we know 5% could be cents. This situation is in marked contrast to the profit driven Western drug markets where products are sold at many times their cost price. As for the vaccine - the fact the same target is being used 30yrs on without a vaccine being finalised shows just how hard it is to vaccinate against malaria. Personally I think the money could have been spent on other approaches, but hindsight is a luxury non one had when the programme started. It is always easy to criticise, but infinitely harder to suggest a better solution.
Bottom line - every day the equivalent of SIX Boeing 747's mostly packed full of children die from malaria. The Gates foundation isn't perfect, but it has literally transformed the world of malaria research and interventions. If you have ever seen a child die from cerebral malaria, you will be glad that anyone is keen to invest in stopping that from happening. I for one am glad the Gates foundation is around...
I could go on, but will stop there!