I swear by unetbootin to run a live distribution. Get image, check md5, in PCLOS fire up unetbootin, select the iso, point it at wherever the usb device is, say obliterate the usb and install, job done. Then its changing the bios boot option to use a usb drive, and away it goes.
Once the live distribution has fired up then it is a typical install.
I like to keep things simple, one image per usb drive, one distribution per machine (and rest on virtualbox if I want to play)
If a particular machine is giving grief then test the usb live device on another machine.
Alternative to use a live disk.