Well, I've been using Linux since 2002(ish) and have distro hopped myself into oblivion
and back again many times over.
Historically I have always preferred Debian/Ubuntu generally. But, PCLOS blows both
distros out of the water!
My hardware is pretty decent (E8400+4GB RAM, Nvidia GTS250) but on Debian/Ubuntu
my fave 3D benchmark, Foobillard, is not nearly as smooth as on PCLOS. This really
impressed me. A small but real world observable difference all the same.
Additionally, Ubuntu's failure to support/integrate JACK in it's libraries is bewildering
at best. Policies eh?

The only weaknesses (generic not PCLOS) that are still apparent to me are:-
Compiz still impacts 3D app performance too much (Nvidia issue I believe)
'Record my deskop' is terrible as ever (all distros I've tried)
'Xvidcap' works but not as a encoded video.
I am using the GNOME variant and I'm very happy with my setup so far.
Thankyou!