Now I am running with Sandy bridge setup, will PCLOS work on it?
The graphics support will be the sore point. See
here. The newer 3.x kernels solve some Sandy bridge problems. But, as you can see from the Intel blog, getting the graphics working correctly is the tricky part.
The best way to find out how well PCLinuxOS will run on your PC is to try a live CD. That will give you some idea.